Evidence for diagnosis of early chronic pancreatitis after three episodes of acute pancreatitis: a cross-sectional multicentre international study with experimental animal model

Animal Models of Acute and Chronic Pancreatitis

Diagnosis of Acute Pancreatitis

Patients with acute pancreatitis (AP) usually present with sudden onset of abdominal pain, nausea, and vomiting. Approximately 80% of patients have interstitial pancreatitis with mild-to-moderate symptoms, and 20% have life-threatening necrotizing disease. Careful clinical assessment and the judicial use of biochemical tests and radiological imaging enables the practitioner to differentiate AP ...

Diagnosis of Acute Pancreatitis

Acute pancreatitis is a common disorder. Its diagnosis, prognosis and management have presented significant challenges to clinicians, surgeons, and radiologists. This article reviews historical and current concepts in the diagnosis of acute pancreatitis and its complications, including radiological diagnosis, as well as the different systems of acute pancreatitis course prediction.

Animal Models of Chronic Pancreatitis

Chronic pancreatitis is a progressive, inflammatory disease of the pancreas, which leads to inflammation and fibrosis, with the potential for exocrine and endocrine insufficiency. The prevalence of the disease is estimated to be 42 per 100,000 and rising (40,105). The pathogenesis of chronic pancreatitis is incompletely understood and complex, involving the interplay of environmental, metabolic...

Animal Models of Chronic Pancreatitis

Animal models for CP in rats can be classified into 2 groups: one is noninvasive or nonsurgical models and the other is invasive or surgical models. Pancreatic injury induced by repetitive injections of supramaximal stimulatory dose of caerulein (Cn) or by intraductal infusion of sodium taurocholate (NaTc) recovered within 14 days, whereas that caused by repetitive injection of arginine or by i...